It's a computational tool used to predict whether an amino acid substitution in a protein will. To use sift for mutation prediction, you need to provide a protein sequence and a list of amino acid substitutions. Sift是预测氨基酸替代是否影响蛋白功能的开放性工具，由a*star（agency for science, technology and research）资金赞助，gis （genome institue of singapore）paulien ng组维.
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The protein sequence can be in fasta format, and the list of substitutions. Sorting intolerant from tolerant (sift) is an algorithm that predicts the potential impact of amino acid substitutions on protein function. We have recently extended sift to predict on.
In the field of genomics , sift is an acronym that stands for sorting intolerant from tolerant.
就是这个网址： sift。 sift根据序列同源性和氨基酸的物理性质预测氨基酸替换是否影响蛋白质功能。 应用于天然存在的非同义多态性和实验室诱导的错义突变。 这里提供了好几个在线的. Sift predicts whether an amino acid substitution affects protein function based on sequence homology and the physical properties of amino acids. Sift can be applied to naturally.
